Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy

Sunil Parikh; Fatai Fehintola; Liusheng Huang; Alexander Olson; Waheed A. Adedeji; Kristin M. Darin; Gene D. Morse; Robert L. Murphy; Babafemi O. Taiwo; Olusegun O. Akinyinka; Isaac F. Adewole; Francesca T. Aweeka; Kimberly K. Scarsi

doi:10.1128/AAC.01153-15

Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy

Sunil Parikh
, Fatai Fehintola
, Liusheng Huang
, Alexander Olson
, Waheed A. Adedeji
, Kristin M. Darin
, Gene D. Morse
, Robert L. Murphy
, Babafemi O. Taiwo
, Olusegun O. Akinyinka
, Isaac F. Adewole
, Francesca T. Aweeka
, Kimberly K. Scarsi

Pharmacy

Yale University
University of Ibadan
University College Hospital, Ibadan
University of California at San Francisco
Northwestern University
University of Nebraska Medical Center

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.

Original language	English
Pages (from-to)	7852-7856
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01153-15
State	Published - Dec 1 2015

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Parikh, S., Fehintola, F., Huang, L., Olson, A., Adedeji, W. A., Darin, K. M., Morse, G. D., Murphy, R. L., Taiwo, B. O., Akinyinka, O. O., Adewole, I. F., Aweeka, F. T., & Scarsi, K. K. (2015). Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy. Antimicrobial Agents and Chemotherapy, 59(12), 7852-7856. https://doi.org/10.1128/AAC.01153-15

@article{e5b238f89d62423bbef250718135ba3d,

title = "Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy",

abstract = "Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.",

author = "Sunil Parikh and Fatai Fehintola and Liusheng Huang and Alexander Olson and Adedeji, \{Waheed A.\} and Darin, \{Kristin M.\} and Morse, \{Gene D.\} and Murphy, \{Robert L.\} and Taiwo, \{Babafemi O.\} and Akinyinka, \{Olusegun O.\} and Adewole, \{Isaac F.\} and Aweeka, \{Francesca T.\} and Scarsi, \{Kimberly K.\}",

year = "2015",

month = dec,

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doi = "10.1128/AAC.01153-15",

language = "English",

volume = "59",

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journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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Parikh, S, Fehintola, F, Huang, L, Olson, A, Adedeji, WA, Darin, KM, Morse, GD, Murphy, RL, Taiwo, BO, Akinyinka, OO, Adewole, IF, Aweeka, FT & Scarsi, KK 2015, 'Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy', Antimicrobial Agents and Chemotherapy, vol. 59, no. 12, pp. 7852-7856. https://doi.org/10.1128/AAC.01153-15

TY - JOUR

T1 - Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy

AU - Parikh, Sunil

AU - Fehintola, Fatai

AU - Huang, Liusheng

AU - Olson, Alexander

AU - Adedeji, Waheed A.

AU - Darin, Kristin M.

AU - Morse, Gene D.

AU - Murphy, Robert L.

AU - Taiwo, Babafemi O.

AU - Akinyinka, Olusegun O.

AU - Adewole, Isaac F.

AU - Aweeka, Francesca T.

AU - Scarsi, Kimberly K.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.

AB - Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.

UR - https://www.scopus.com/pages/publications/84954519333

U2 - 10.1128/AAC.01153-15

DO - 10.1128/AAC.01153-15

M3 - Article

C2 - 26392500

AN - SCOPUS:84954519333

SN - 0066-4804

VL - 59

SP - 7852

EP - 7856

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Artemether-lumefantrine exposure in HIV-infected nigerian subjects on nevirapine-containing antiretroviral therapy

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