Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats

Michal K. Stachowiak; John P. Bruno; Abigail M. Snyder; Edward M. Stricker; Michael J. Zigmond

doi:10.1016/0006-8993(84)90665-6

Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats

Michal K. Stachowiak
, John P. Bruno
, Abigail M. Snyder
, Edward M. Stricker
, Michael J. Zigmond

Department of Pathology and Anatomical Sciences

University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

226 Scopus citations

Abstract

Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lessions were produced in adult rats.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Brain Research
Volume	291
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90665-6
State	Published - Jan 16 1984

Keywords

6-hydroxydopamine
development
dopamine depletions
plasticity
serotonin
sprouting
striatum

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10.1016/0006-8993(84)90665-6

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title = "Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats",

abstract = "Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lessions were produced in adult rats.",

keywords = "6-hydroxydopamine, development, dopamine depletions, plasticity, serotonin, sprouting, striatum",

author = "Stachowiak, \{Michal K.\} and Bruno, \{John P.\} and Snyder, \{Abigail M.\} and Stricker, \{Edward M.\} and Zigmond, \{Michael J.\}",

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AU - Stachowiak, Michal K.

AU - Bruno, John P.

AU - Snyder, Abigail M.

AU - Stricker, Edward M.

AU - Zigmond, Michael J.

PY - 1984/1/16

Y1 - 1984/1/16

N2 - Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lessions were produced in adult rats.

AB - Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lessions were produced in adult rats.

KW - 6-hydroxydopamine

KW - development

KW - dopamine depletions

KW - plasticity

KW - serotonin

KW - sprouting

KW - striatum

UR - https://www.scopus.com/pages/publications/0021334307

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AN - SCOPUS:0021334307

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SP - 164

EP - 167

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats

Abstract

Keywords

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