Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin

Young Jae You; Yong Kim; Nguyen Hai Nam; Byung Zun Ahn

doi:10.1016/S0960-894X(03)00558-4

Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin

Young Jae You
, Yong Kim
, Nguyen Hai Nam
, Byung Zun Ahn

Pharmaceutical Sciences

Chungnam National University
SBP Pharmaceutical Company

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.

Original language	English
Pages (from-to)	2629-2632
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(03)00558-4
State	Published - Aug 18 2003

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title = "Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin",

abstract = "Unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83\%) than VP-16 (IR, 60\%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.",

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T1 - Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin

AU - You, Young Jae

AU - Kim, Yong

AU - Nam, Nguyen Hai

AU - Ahn, Byung Zun

PY - 2003/8/18

Y1 - 2003/8/18

N2 - Unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.

AB - Unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.

UR - https://www.scopus.com/pages/publications/0037811439

U2 - 10.1016/S0960-894X(03)00558-4

DO - 10.1016/S0960-894X(03)00558-4

M3 - Article

C2 - 12873481

AN - SCOPUS:0037811439

SN - 0960-894X

VL - 13

SP - 2629

EP - 2632

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Antitumor activity of unsaturated fatty acid esters of 4′-demethyldeoxypodophyllotoxin

Abstract

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