Antileukemic Activity of Derivatives of 1, 2-Dimethy1-3, 4-bis(hydroxymethyl)-5-phenylpyrrole Bis(N-methylcarbamate)

A series of phenyl-substituted derivatives of 1, 2-dimethyl-3, 4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a-r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined.