TY - JOUR
T1 - Antifungal persistence
T2 - Clinical relevance and mechanisms
AU - Wang, Rui
AU - Lv, Jingnan
AU - Chen, Liang
AU - Zhao, Yanan
AU - Du, Hong
N1 - Publisher Copyright:
© 2025 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2025/9
Y1 - 2025/9
N2 - Antifungal persistence is the phenomenon that occurs when a subpopulation of fungal cells can survive in the presence of high concentrations of antifungal drugs, which is different from the concepts of antifungal resistance and tolerance. Fungal persisters are not mutants but phenotypic variants of normal cells, entering a dormant state with low metabolism and proliferation. Previous studies have shown that antifungal persistence may lead to therapeutic failure, as well as chronic or recurrent fungal infections in clinical settings. This review provides a comprehensive overview of antifungal persistence covering its definition, distinctions from other related concepts, detection methods, and molecular mechanisms of formation. Importantly, we discuss relevant in vivo experiments and clinical observations to assess clinical relevance of antifungal persistence.
AB - Antifungal persistence is the phenomenon that occurs when a subpopulation of fungal cells can survive in the presence of high concentrations of antifungal drugs, which is different from the concepts of antifungal resistance and tolerance. Fungal persisters are not mutants but phenotypic variants of normal cells, entering a dormant state with low metabolism and proliferation. Previous studies have shown that antifungal persistence may lead to therapeutic failure, as well as chronic or recurrent fungal infections in clinical settings. This review provides a comprehensive overview of antifungal persistence covering its definition, distinctions from other related concepts, detection methods, and molecular mechanisms of formation. Importantly, we discuss relevant in vivo experiments and clinical observations to assess clinical relevance of antifungal persistence.
UR - https://www.scopus.com/pages/publications/105015631273
U2 - 10.1371/journal.ppat.1013456
DO - 10.1371/journal.ppat.1013456
M3 - Review article
C2 - 40934262
AN - SCOPUS:105015631273
SN - 1553-7366
VL - 21
JO - PLOS Pathogens
JF - PLOS Pathogens
IS - 9 September
M1 - e1013456
ER -