Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire

Ketan D. Patel; Andrew M. Gulick

doi:10.1016/j.jbc.2021.101047

Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire

Ketan D. Patel
, Andrew M. Gulick

Department of Structural Biology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication.

Original language	English
Article number	101047
Journal	Journal of Biological Chemistry
Volume	297
Issue number	3
DOIs	https://doi.org/10.1016/j.jbc.2021.101047
State	Published - Sep 1 2021

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abstract = "The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication.",

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Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire

Abstract

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