Animal models in congenital diaphragmatic hernia

The first animal model of congenital diaphragmatic hernia (CDH) was described in 1967. This was a late-gestational, surgically-created lamb model. Since then, animal modeling has become more sophisticated. Using a variety of techniques and laboratory species, animal models have been produced to investigate the pathophysiology of CDH, from whole animal physiology studies to lung molecular changes. To provide the animal tissue required, three different approaches have been used: (1) a surgically created model which has been reported in lambs and rabbits, (2) a teratogen-induced model which to date has been described in rats and mice, and (3) a congenital model which is present in a specific pig herd. All animal models are discussed in this article.