TY - JOUR
T1 - An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling
AU - Kurniansyah, Nuzulul
AU - Wallace, Danielle A.
AU - Zhang, Ying
AU - Yu, Bing
AU - Cade, Brian
AU - Wang, Heming
AU - Ochs-Balcom, Heather M.
AU - Reiner, Alexander P.
AU - Ramos, Alberto R.
AU - Smith, Joshua D.
AU - Cai, Jianwen
AU - Daviglus, Martha
AU - Zee, Phyllis C.
AU - Kaplan, Robert
AU - Kooperberg, Charles
AU - Rich, Stephen S.
AU - Rotter, Jerome I.
AU - Gharib, Sina A.
AU - Redline, Susan
AU - Sofer, Tamar
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women’s Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and link P2XR4 expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.
AB - Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women’s Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and link P2XR4 expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.
UR - https://www.scopus.com/pages/publications/85147096094
U2 - 10.1038/s42003-023-04520-y
DO - 10.1038/s42003-023-04520-y
M3 - Article
C2 - 36721044
AN - SCOPUS:85147096094
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 125
ER -