An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

Gergely M. Makara; Kevin Klubek; Wayne K. Anderson

doi:10.1080/00397919608003548

An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

Gergely M. Makara
, Kevin Klubek
, Wayne K. Anderson

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55% overall yield.

Original language	English
Pages (from-to)	1935-1942
Number of pages	8
Journal	Synthetic Communications
Volume	26
Issue number	10
DOIs	https://doi.org/10.1080/00397919608003548
State	Published - 1996

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title = "An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid",

abstract = "An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55\% overall yield.",

author = "Makara, \{Gergely M.\} and Kevin Klubek and Anderson, \{Wayne K.\}",

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T1 - An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

AU - Makara, Gergely M.

AU - Klubek, Kevin

AU - Anderson, Wayne K.

PY - 1996

Y1 - 1996

N2 - An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55% overall yield.

AB - An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55% overall yield.

UR - https://www.scopus.com/pages/publications/0029970167

U2 - 10.1080/00397919608003548

DO - 10.1080/00397919608003548

M3 - Article

AN - SCOPUS:0029970167

SN - 0039-7911

VL - 26

SP - 1935

EP - 1942

JO - Synthetic Communications

JF - Synthetic Communications

IS - 10

ER -

An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

Abstract

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