An area function method for calculating the apparent elimination rate constant of a metabolite

Haiyung Cheng; William J. Jusko

doi:10.1007/BF01059091

An area function method for calculating the apparent elimination rate constant of a metabolite

Haiyung Cheng
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo
Merrell Dow Pharmaceuticals Inc.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A simple method for determination of the apparent elimination rate constant of a metabolite (k_m) has been developed. This procedure requires calculation of area intervals under the plasma concentration-time curves of the parent drug and its derived metabolite. The method has been evaluated and compared with the Chan moment method using both errorless and errant data. The approach is accurate for various ratios of elimination rate constants of drug and metabolite, allows several values of k_m to be averaged, but works best using data prior to the metabolite t ax.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Journal of Pharmacokinetics and Biopharmaceutics
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/BF01059091
State	Published - Feb 1989

Keywords

apparent metabolite elimination rate constant
area function method
metabolite kinetics
moment analysis
one-compartment model

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10.1007/BF01059091

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abstract = "A simple method for determination of the apparent elimination rate constant of a metabolite (km) has been developed. This procedure requires calculation of area intervals under the plasma concentration-time curves of the parent drug and its derived metabolite. The method has been evaluated and compared with the Chan moment method using both errorless and errant data. The approach is accurate for various ratios of elimination rate constants of drug and metabolite, allows several values of km to be averaged, but works best using data prior to the metabolite t ax.",

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AB - A simple method for determination of the apparent elimination rate constant of a metabolite (km) has been developed. This procedure requires calculation of area intervals under the plasma concentration-time curves of the parent drug and its derived metabolite. The method has been evaluated and compared with the Chan moment method using both errorless and errant data. The approach is accurate for various ratios of elimination rate constants of drug and metabolite, allows several values of km to be averaged, but works best using data prior to the metabolite t ax.

KW - apparent metabolite elimination rate constant

KW - area function method

KW - metabolite kinetics

KW - moment analysis

KW - one-compartment model

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JF - Journal of Pharmacokinetics and Biopharmaceutics

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ER -

An area function method for calculating the apparent elimination rate constant of a metabolite

Abstract

Keywords

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