TY - GEN
T1 - AN ANTI-FOULING AIRWAY STENT
AU - Glumac, Daniel
AU - Kadowaki, Koji
AU - Cho, Roy
AU - Peterson, Gregory
AU - Hunter, Ryan
AU - Kent, Leslie
AU - MacIver, Robroy
AU - Pandey, Vidhu
AU - Tanahashi, Kazuhiro
N1 - Publisher Copyright:
© 2022 by ASME
PY - 2022
Y1 - 2022
N2 - Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.
AB - Airway stents are used to keep airways open for those patients symptomatic from tracheobronchial disease. Tracheobronchial disease or central airway obstruction (CAO) can occur with benign or malignant disease, or complications from lung transplantation. Although stents can offer symptomatic relief for CAO, complications such as granulation tissue formation, stent fracture, and infection commonly occur after stent placement. Currently, all airway stents promote mucus buildup which can lead to stent failure and airway complications. In this paper, we demonstrate the use of special anti-fouling coatings to prevent mucus buildup. The coatings have been tested: 1) for wettability, 2) using XPS and TOF-SIMS to characterize surface properties, and 3) in the laboratory (in vitro) to study effects of mucin incubation. Findings include significant improvement in limiting mucus adhesion in a lab model.
KW - airway stent
KW - anti-fouling
KW - mucus
UR - https://www.scopus.com/pages/publications/85130276033
U2 - 10.1115/DMD2022-1031
DO - 10.1115/DMD2022-1031
M3 - Conference contribution
AN - SCOPUS:85130276033
T3 - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
BT - Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
PB - American Society of Mechanical Engineers
T2 - 2022 Design of Medical Devices Conference, DMD 2022
Y2 - 11 April 2022 through 14 April 2022
ER -