Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia

M. B. Kristal; A. C. Thompson; P. Abbott; J. M. Di Pirro; E. J. Ferguson; J. C. Doerr

doi:10.1016/0024-3205(90)90074-2

Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia

M. B. Kristal
, A. C. Thompson
, P. Abbott
, J. M. Di Pirro
, E. J. Ferguson
, J. C. Doerr

Psychology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml; and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.

Original language	English
Pages (from-to)	693-698
Number of pages	6
Journal	Life Sciences
Volume	46
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(90)90074-2
State	Published - 1990

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title = "Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia",

abstract = "Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml; and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.",

author = "Kristal, \{M. B.\} and Thompson, \{A. C.\} and P. Abbott and \{Di Pirro\}, \{J. M.\} and Ferguson, \{E. J.\} and Doerr, \{J. C.\}",

year = "1990",

doi = "10.1016/0024-3205(90)90074-2",

language = "English",

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TY - JOUR

T1 - Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia

AU - Kristal, M. B.

AU - Thompson, A. C.

AU - Abbott, P.

AU - Di Pirro, J. M.

AU - Ferguson, E. J.

AU - Doerr, J. C.

PY - 1990

Y1 - 1990

N2 - Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml; and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.

AB - Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml; and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.

UR - https://www.scopus.com/pages/publications/0025214588

U2 - 10.1016/0024-3205(90)90074-2

DO - 10.1016/0024-3205(90)90074-2

M3 - Article

C2 - 2314190

AN - SCOPUS:0025214588

SN - 0024-3205

VL - 46

SP - 693

EP - 698

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia

Abstract

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