Abstract
The present study clearly shows that, by feeding rats a semi-synthetic diet of known composition enriched with saturated fatty acids, the epididymal fat pad responsiveness to norepinephrine in vitro can be abolished relative to fat pads from animals fed a similar diet but enriched with polyunsaturated fatty acids. Addition of varying concentrations of norepinephrine to the incubation medium produced a clear dose-response relationship in fat pads from animals fed diet enriched with polyunsaturated fatty acids while no effect of norepinephrine was apparent at any dose level in fat tissue from animals fed saturated fatty acids. These changes in lipolytic responsiveness were concurrent with alterations in fatty acid compositions of adipose tissue phospholipids and triglycerides as well as in total tissue contents of phospholipids and cholesterol.
| Original language | English |
|---|---|
| Pages (from-to) | 138-144 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 86 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 15 1979 |
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