Allylic Esters as Potential Antitumor Agents. Derivatives and Analogues of 2, 3-Bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene

Wayne K. Anderson; Richard H. Dewey; Bipi Mulumba

doi:10.1021/jm00196a024

Allylic Esters as Potential Antitumor Agents. Derivatives and Analogues of 2, 3-Bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene

Wayne K. Anderson
, Richard H. Dewey
, Bipi Mulumba

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10^-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity.

Original language	English
Pages (from-to)	1270-1272
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	22
Issue number	10
DOIs	https://doi.org/10.1021/jm00196a024
State	Published - Feb 1 1979

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title = "Allylic Esters as Potential Antitumor Agents. Derivatives and Analogues of 2, 3-Bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene",

abstract = "Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93\% inhibition at 10-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity.",

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T1 - Allylic Esters as Potential Antitumor Agents. Derivatives and Analogues of 2, 3-Bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene

AU - Anderson, Wayne K.

AU - Dewey, Richard H.

AU - Mulumba, Bipi

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Y1 - 1979/2/1

N2 - Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity.

AB - Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity.

UR - https://www.scopus.com/pages/publications/0018671160

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ER -

Allylic Esters as Potential Antitumor Agents. Derivatives and Analogues of 2, 3-Bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene

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