TY - JOUR
T1 - Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project
AU - Dalmartello, Michela
AU - Turati, Federica
AU - Zhang, Zuo Feng
AU - Lunet, Nuno
AU - Rota, Matteo
AU - Bonzi, Rossella
AU - Galeone, Carlotta
AU - Martimianaki, Georgia
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Yu, Guo Pei
AU - Morais, Samantha
AU - Malekzadeh, Reza
AU - López-Carrillo, Lizbeth
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Aragonés, Nuria
AU - Fernández-Tardón, Guillermo
AU - Martin, Vicente
AU - Vioque, Jesus
AU - Garcia de la Hera, Manoli
AU - Curado, Maria Paula
AU - Coimbra, Felipe Jose Fernandez
AU - Assumpcao, Paulo
AU - Pakseresht, Mohammadreza
AU - Hu, Jinfu
AU - Hernández-Ramírez, Raúl Ulises
AU - Ward, Mary H.
AU - Pourfarzi, Farhad
AU - Mu, Lina
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Lagiou, Pagona
AU - Lagiou, Areti
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Boffetta, Paolo
AU - Camargo, M. Costanza
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Pelucchi, Claudio
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the “Stomach cancer Pooling (StoP) Project”, including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56–0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55–0.86) for onions and 0.83 (95% CI, 0.75–0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29–0.86) but not European (OR 0.96, 95% CI, 0.81–1.13) and American (OR 0.66, 95% CI, 0.39–1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
AB - Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the “Stomach cancer Pooling (StoP) Project”, including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56–0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55–0.86) for onions and 0.83 (95% CI, 0.75–0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29–0.86) but not European (OR 0.96, 95% CI, 0.81–1.13) and American (OR 0.66, 95% CI, 0.39–1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
UR - https://www.scopus.com/pages/publications/85125138901
U2 - 10.1038/s41416-022-01750-5
DO - 10.1038/s41416-022-01750-5
M3 - Article
C2 - 35210588
AN - SCOPUS:85125138901
SN - 0007-0920
VL - 126
SP - 1755
EP - 1764
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 12
ER -