Allergenic components of bald-faced hornet (V. maculata) venom

Susan Littler; John I. Wypych; Robert W. Noble; C. John Abeyounis; Robert E. Reisman

doi:10.1159/000233652

Allergenic components of bald-faced hornet (V. maculata) venom

Susan Littler
, John I. Wypych
, Robert W. Noble
, C. John Abeyounis
, Robert E. Reisman

Medicine

SUNY Buffalo
Women and Children's Hospital of Buffalo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Bald-faced hornet (V. maculata) venom collected by electrical stimulation was fractionated using molecular exclusion gel-filtration and ion-exchange chromatography. Four fractions were selected for indepth analysis. These were analyzed for phospholipase, hyaluronidase and protease enzyme activities, antigenicity as measured by reaction with anti-hornet venom rabbit serum, and allergenic activity, as determined by RAST reaction with sera from hornet-sensitive patients. The results of these studies suggest that the fractions containing phospholipase, hyaluronidase and protease possess allergenic activity. In addition, there appear to be other allergenic components in hornet venom. Allergic patients differ in their reactivity to the various allergenic components in hornet venom and may have IgE antibodies to one or more of these components.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	International Archives of Allergy and Immunology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1159/000233652
State	Published - 1985

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title = "Allergenic components of bald-faced hornet (V. maculata) venom",

abstract = "Bald-faced hornet (V. maculata) venom collected by electrical stimulation was fractionated using molecular exclusion gel-filtration and ion-exchange chromatography. Four fractions were selected for indepth analysis. These were analyzed for phospholipase, hyaluronidase and protease enzyme activities, antigenicity as measured by reaction with anti-hornet venom rabbit serum, and allergenic activity, as determined by RAST reaction with sera from hornet-sensitive patients. The results of these studies suggest that the fractions containing phospholipase, hyaluronidase and protease possess allergenic activity. In addition, there appear to be other allergenic components in hornet venom. Allergic patients differ in their reactivity to the various allergenic components in hornet venom and may have IgE antibodies to one or more of these components.",

author = "Susan Littler and Wypych, \{John I.\} and Noble, \{Robert W.\} and \{John Abeyounis\}, C. and Reisman, \{Robert E.\}",

year = "1985",

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T1 - Allergenic components of bald-faced hornet (V. maculata) venom

AU - Littler, Susan

AU - Wypych, John I.

AU - Noble, Robert W.

AU - John Abeyounis, C.

AU - Reisman, Robert E.

PY - 1985

Y1 - 1985

N2 - Bald-faced hornet (V. maculata) venom collected by electrical stimulation was fractionated using molecular exclusion gel-filtration and ion-exchange chromatography. Four fractions were selected for indepth analysis. These were analyzed for phospholipase, hyaluronidase and protease enzyme activities, antigenicity as measured by reaction with anti-hornet venom rabbit serum, and allergenic activity, as determined by RAST reaction with sera from hornet-sensitive patients. The results of these studies suggest that the fractions containing phospholipase, hyaluronidase and protease possess allergenic activity. In addition, there appear to be other allergenic components in hornet venom. Allergic patients differ in their reactivity to the various allergenic components in hornet venom and may have IgE antibodies to one or more of these components.

AB - Bald-faced hornet (V. maculata) venom collected by electrical stimulation was fractionated using molecular exclusion gel-filtration and ion-exchange chromatography. Four fractions were selected for indepth analysis. These were analyzed for phospholipase, hyaluronidase and protease enzyme activities, antigenicity as measured by reaction with anti-hornet venom rabbit serum, and allergenic activity, as determined by RAST reaction with sera from hornet-sensitive patients. The results of these studies suggest that the fractions containing phospholipase, hyaluronidase and protease possess allergenic activity. In addition, there appear to be other allergenic components in hornet venom. Allergic patients differ in their reactivity to the various allergenic components in hornet venom and may have IgE antibodies to one or more of these components.

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JO - International Archives of Allergy and Immunology

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Allergenic components of bald-faced hornet (V. maculata) venom

Abstract

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