Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxic, and antitumor activity

Young Jae You; Yong Kim; Nguyen Hai Nam; Seong Cheol Bang; Byung Zun Ahn

doi:10.1016/j.ejmech.2003.10.002

Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxic, and antitumor activity

Young Jae You
, Yong Kim
, Nguyen Hai Nam
, Seong Cheol Bang
, Byung Zun Ahn

Pharmaceutical Sciences

Chungnam National University
SBP Pharmaceutical Company

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Esters of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.ejmech.2003.10.002
State	Published - Feb 2004

Keywords

Antitumor activity
Cytotoxicity
Deoxypodophyllotoxin
Esters

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10.1016/j.ejmech.2003.10.002

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title = "Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxic, and antitumor activity",

abstract = "Esters of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT.",

keywords = "Antitumor activity, Cytotoxicity, Deoxypodophyllotoxin, Esters",

author = "You, \{Young Jae\} and Yong Kim and Nam, \{Nguyen Hai\} and Bang, \{Seong Cheol\} and Ahn, \{Byung Zun\}",

year = "2004",

month = feb,

doi = "10.1016/j.ejmech.2003.10.002",

language = "English",

volume = "39",

pages = "189--193",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

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}

TY - JOUR

T1 - Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin

T2 - Synthesis, cytotoxic, and antitumor activity

AU - You, Young Jae

AU - Kim, Yong

AU - Nam, Nguyen Hai

AU - Bang, Seong Cheol

AU - Ahn, Byung Zun

PY - 2004/2

Y1 - 2004/2

N2 - Esters of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT.

AB - Esters of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) with alkanoic acids and alkanedioic acids were prepared and tested for cytotoxic and antitumor activity. Among 19 esters, esters of propanoic acid, tetradecanedioic acid, 13-carboxyundecanoic acid, and hexadecanedioic acid improved the antitumor activity compared with that of the starting compounds, DDPT.

KW - Antitumor activity

KW - Cytotoxicity

KW - Deoxypodophyllotoxin

KW - Esters

UR - https://www.scopus.com/pages/publications/1342281649

U2 - 10.1016/j.ejmech.2003.10.002

DO - 10.1016/j.ejmech.2003.10.002

M3 - Article

C2 - 14987827

AN - SCOPUS:1342281649

SN - 0223-5234

VL - 39

SP - 189

EP - 193

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 2

ER -

Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxic, and antitumor activity

Abstract

Keywords

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