Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens

K. Murali Krishna Rao; Stanley A. Schwartz; Robert A. Good

doi:10.1016/0008-8749(79)90192-8

Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens

K. Murali Krishna Rao
, Stanley A. Schwartz
, Robert A. Good

Medicine

Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The addition of zinc to human peripheral blood lymphocytes (PBL) stimulated with mitogens demonstrated an age-dependent effect on blastogenesis. PBL from young persons showed either no change or an enhancement in the mitogenic response whereas blastogenesis by PBL from aged donors was suppressed by zinc. It is likely that the action of zinc might be due to its effects on the surface membrane of lymphocytes. Thus, zinc might serve as a useful probe for studying membrane changes associated with aging.

Original language	English
Pages (from-to)	270-278
Number of pages	9
Journal	Cellular Immunology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(79)90192-8
State	Published - Feb 1979

Access to Document

10.1016/0008-8749(79)90192-8

Cite this

@article{2183d452795143f2af4de2695ab12aa6,

title = "Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens",

abstract = "The addition of zinc to human peripheral blood lymphocytes (PBL) stimulated with mitogens demonstrated an age-dependent effect on blastogenesis. PBL from young persons showed either no change or an enhancement in the mitogenic response whereas blastogenesis by PBL from aged donors was suppressed by zinc. It is likely that the action of zinc might be due to its effects on the surface membrane of lymphocytes. Thus, zinc might serve as a useful probe for studying membrane changes associated with aging.",

author = "\{Murali Krishna Rao\}, K. and Schwartz, \{Stanley A.\} and Good, \{Robert A.\}",

year = "1979",

month = feb,

doi = "10.1016/0008-8749(79)90192-8",

language = "English",

volume = "42",

pages = "270--278",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens

AU - Murali Krishna Rao, K.

AU - Schwartz, Stanley A.

AU - Good, Robert A.

PY - 1979/2

Y1 - 1979/2

N2 - The addition of zinc to human peripheral blood lymphocytes (PBL) stimulated with mitogens demonstrated an age-dependent effect on blastogenesis. PBL from young persons showed either no change or an enhancement in the mitogenic response whereas blastogenesis by PBL from aged donors was suppressed by zinc. It is likely that the action of zinc might be due to its effects on the surface membrane of lymphocytes. Thus, zinc might serve as a useful probe for studying membrane changes associated with aging.

AB - The addition of zinc to human peripheral blood lymphocytes (PBL) stimulated with mitogens demonstrated an age-dependent effect on blastogenesis. PBL from young persons showed either no change or an enhancement in the mitogenic response whereas blastogenesis by PBL from aged donors was suppressed by zinc. It is likely that the action of zinc might be due to its effects on the surface membrane of lymphocytes. Thus, zinc might serve as a useful probe for studying membrane changes associated with aging.

UR - https://www.scopus.com/pages/publications/0018413655

U2 - 10.1016/0008-8749(79)90192-8

DO - 10.1016/0008-8749(79)90192-8

M3 - Article

C2 - 427879

AN - SCOPUS:0018413655

SN - 0008-8749

VL - 42

SP - 270

EP - 278

JO - Cellular Immunology

JF - Cellular Immunology

IS - 2

ER -

Age-dependent effects of zinc on the transformation response of human lymphocytes to mitogens

Abstract

Access to Document

Other files and links

Fingerprint

Cite this