TY - CHAP
T1 - Advances in NMR-based structural genomics
AU - Szyperski, Thomas
AU - Montelione, Gaetano T.
PY - 2011
Y1 - 2011
N2 - Structural genomics requires that accurate atomic resolution protein structures are solved in high-throughput. The Northeast Structural Genomics Consortium (NESG), USA, has established a scalable platform for NMR-based structure determination, including protocols for rapid NMR data acquisition, semi-automated data processing, data analysis and structure calculation, and structure validation. The main features of this pipeline are discussed along with (i) recent methodological advances and (ii) perspectives for future improvements and expansion to larger bio-molecular systems.
AB - Structural genomics requires that accurate atomic resolution protein structures are solved in high-throughput. The Northeast Structural Genomics Consortium (NESG), USA, has established a scalable platform for NMR-based structure determination, including protocols for rapid NMR data acquisition, semi-automated data processing, data analysis and structure calculation, and structure validation. The main features of this pipeline are discussed along with (i) recent methodological advances and (ii) perspectives for future improvements and expansion to larger bio-molecular systems.
KW - Automated data analysis and structure calculation
KW - data acquisition
KW - NMR
KW - structural genomics
UR - https://www.scopus.com/pages/publications/84865449634
U2 - 10.3233/978-1-60750-695-9-366
DO - 10.3233/978-1-60750-695-9-366
M3 - Chapter
AN - SCOPUS:84865449634
SN - 9781607506942
T3 - Advances in Biomedical Spectroscopy
SP - 366
EP - 380
BT - Biomolecular NMR Spectroscopy
ER -