Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia: Does -lactam class matter?

Thomas J. Dilworth; Anthony M. Casapao; Omar M. Ibrahim; David M. Jacobs; Dana R. Bowers; Nicholas D. Beyda; Renee Claude Mercier

doi:10.1128/AAC.02211-18

Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia: Does -lactam class matter?

Thomas J. Dilworth
, Anthony M. Casapao
, Omar M. Ibrahim
, David M. Jacobs
, Dana R. Bowers
, Nicholas D. Beyda
, Renee Claude Mercier

Pharmacy

Aurora Health Care
University of Florida
Independent Researcher
Washington State University Spokane
University of Houston
University of New Mexico

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We analyzed the impact of vancomycin (VAN) combined with adjuvant -lactam therapy (Combo) on persistent (5 days) methicillin-resistant Staphylococcus aureus bacteremia versus VAN alone by using pooled data from two previously published observational studies (n 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; P 0.062).

Original language	English
Article number	e02211-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	3
DOIs	https://doi.org/10.1128/AAC.02211-18
State	Published - Mar 2019

Keywords

Bacteremia
Combination therapy
Lactam
Methicillin-resistant Staphylococcus aureus
Vancomycin

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10.1128/AAC.02211-18

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title = "Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia: Does -lactam class matter?",

abstract = "We analyzed the impact of vancomycin (VAN) combined with adjuvant -lactam therapy (Combo) on persistent (5 days) methicillin-resistant Staphylococcus aureus bacteremia versus VAN alone by using pooled data from two previously published observational studies (n 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95\% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9\% and 7.6\%, respectively; P 0.062).",

keywords = "Bacteremia, Combination therapy, Lactam, Methicillin-resistant Staphylococcus aureus, Vancomycin",

author = "Dilworth, \{Thomas J.\} and Casapao, \{Anthony M.\} and Ibrahim, \{Omar M.\} and Jacobs, \{David M.\} and Bowers, \{Dana R.\} and Beyda, \{Nicholas D.\} and Mercier, \{Renee Claude\}",

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doi = "10.1128/AAC.02211-18",

language = "English",

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T1 - Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia

T2 - Does -lactam class matter?

AU - Dilworth, Thomas J.

AU - Casapao, Anthony M.

AU - Ibrahim, Omar M.

AU - Jacobs, David M.

AU - Bowers, Dana R.

AU - Beyda, Nicholas D.

AU - Mercier, Renee Claude

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N2 - We analyzed the impact of vancomycin (VAN) combined with adjuvant -lactam therapy (Combo) on persistent (5 days) methicillin-resistant Staphylococcus aureus bacteremia versus VAN alone by using pooled data from two previously published observational studies (n 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; P 0.062).

AB - We analyzed the impact of vancomycin (VAN) combined with adjuvant -lactam therapy (Combo) on persistent (5 days) methicillin-resistant Staphylococcus aureus bacteremia versus VAN alone by using pooled data from two previously published observational studies (n 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; P 0.062).

KW - Bacteremia

KW - Combination therapy

KW - Lactam

KW - Methicillin-resistant Staphylococcus aureus

KW - Vancomycin

UR - https://www.scopus.com/pages/publications/85062287470

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DO - 10.1128/AAC.02211-18

M3 - Article

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AN - SCOPUS:85062287470

SN - 0066-4804

VL - 63

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e02211-18

ER -

Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia: Does -lactam class matter?

Abstract

Keywords

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