Adipose tissue and anti-inflammatory pharmacotherapy

Peter G. Bradford; Atif B. Awad

doi:10.1201/9781420091311.ch15

Adipose tissue and anti-inflammatory pharmacotherapy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The hypothesis that low grade chronic systemic inflammation involving adipocytederived factors links obesity to clinical metabolic disorders is attracting growing support. Observational and experimental models of obesity have revealed that significant amounts of pro-inflammatory mediators are synthesized and secreted by adipose tissue. It is hypothesized that the release of pro-inflammatory adipokines and the cessation of synthesis of normally anti-inflammatory mediators may be caused by adipocyte hypertrophy or hyperplasia that promotes local hypoxia and cellular stress (de Luca and Olefsky, 2008).

Original language	English
Title of host publication	Adipose Tissue and Inflammation
Publisher	CRC Press
Pages	285-296
Number of pages	12
ISBN (Electronic)	9781420091311
ISBN (Print)	9781420091304
DOIs	https://doi.org/10.1201/9781420091311.ch15
State	Published - Jan 1 2009

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abstract = "The hypothesis that low grade chronic systemic inflammation involving adipocytederived factors links obesity to clinical metabolic disorders is attracting growing support. Observational and experimental models of obesity have revealed that significant amounts of pro-inflammatory mediators are synthesized and secreted by adipose tissue. It is hypothesized that the release of pro-inflammatory adipokines and the cessation of synthesis of normally anti-inflammatory mediators may be caused by adipocyte hypertrophy or hyperplasia that promotes local hypoxia and cellular stress (de Luca and Olefsky, 2008).",

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AB - The hypothesis that low grade chronic systemic inflammation involving adipocytederived factors links obesity to clinical metabolic disorders is attracting growing support. Observational and experimental models of obesity have revealed that significant amounts of pro-inflammatory mediators are synthesized and secreted by adipose tissue. It is hypothesized that the release of pro-inflammatory adipokines and the cessation of synthesis of normally anti-inflammatory mediators may be caused by adipocyte hypertrophy or hyperplasia that promotes local hypoxia and cellular stress (de Luca and Olefsky, 2008).

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BT - Adipose Tissue and Inflammation

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ER -

Adipose tissue and anti-inflammatory pharmacotherapy

Abstract

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