Addition of trimethylsilyl cyanide to α-substituted ketones: Catalyst efficiency

W. J. Greenlee; D. G. Hangauer

doi:10.1016/S0040-4039(00)85954-7

Addition of trimethylsilyl cyanide to α-substituted ketones: Catalyst efficiency

W. J. Greenlee
, D. G. Hangauer

Chemistry

Merck

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Addition of trimethylsilyl cyanide to α-substituted ketones is often slow and incomplete when catalyzed by zinc iodide. Use of potassium cyanide/18-crown-6 complex as catalyst is a superior method, providing high yields of adducts.

Original language	English
Pages (from-to)	4559-4560
Number of pages	2
Journal	Tetrahedron Letters
Volume	24
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(00)85954-7
State	Published - 1983

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title = "Addition of trimethylsilyl cyanide to α-substituted ketones: Catalyst efficiency",

abstract = "Addition of trimethylsilyl cyanide to α-substituted ketones is often slow and incomplete when catalyzed by zinc iodide. Use of potassium cyanide/18-crown-6 complex as catalyst is a superior method, providing high yields of adducts.",

author = "Greenlee, \{W. J.\} and Hangauer, \{D. G.\}",

year = "1983",

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journal = "Tetrahedron Letters",

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T1 - Addition of trimethylsilyl cyanide to α-substituted ketones

T2 - Catalyst efficiency

AU - Greenlee, W. J.

AU - Hangauer, D. G.

PY - 1983

Y1 - 1983

N2 - Addition of trimethylsilyl cyanide to α-substituted ketones is often slow and incomplete when catalyzed by zinc iodide. Use of potassium cyanide/18-crown-6 complex as catalyst is a superior method, providing high yields of adducts.

AB - Addition of trimethylsilyl cyanide to α-substituted ketones is often slow and incomplete when catalyzed by zinc iodide. Use of potassium cyanide/18-crown-6 complex as catalyst is a superior method, providing high yields of adducts.

UR - https://www.scopus.com/pages/publications/0000894714

U2 - 10.1016/S0040-4039(00)85954-7

DO - 10.1016/S0040-4039(00)85954-7

M3 - Article

AN - SCOPUS:0000894714

SN - 0040-4039

VL - 24

SP - 4559

EP - 4560

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Addition of trimethylsilyl cyanide to α-substituted ketones: Catalyst efficiency

Abstract

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