Adaptation to hyperosmolality in the rat

Alan H. Lockwood

doi:10.1016/0006-8993(80)91112-9

Adaptation to hyperosmolality in the rat

Alan H. Lockwood

Neurology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Hyperosmolality induced in rats results in a progressive increase in brain glutamine levels with out a change in ammonia. This suggests an adaptation in the compartmental nature of the glutamate-ammonia-glutamine metabolic system to provide more brain osmoles without excess ammonia. The brain: blood glucose ratio rose suggesting brain energy use rate reductions previously reported may be due to altered glucose transport or phosphorylation.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	Brain Research
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)91112-9
State	Published - Oct 27 1980

Keywords

brain ammonia
brain glucose
brain glutamine
compartmentation
hyperosmolality
metabolic

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10.1016/0006-8993(80)91112-9

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title = "Adaptation to hyperosmolality in the rat",

abstract = "Hyperosmolality induced in rats results in a progressive increase in brain glutamine levels with out a change in ammonia. This suggests an adaptation in the compartmental nature of the glutamate-ammonia-glutamine metabolic system to provide more brain osmoles without excess ammonia. The brain: blood glucose ratio rose suggesting brain energy use rate reductions previously reported may be due to altered glucose transport or phosphorylation.",

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AB - Hyperosmolality induced in rats results in a progressive increase in brain glutamine levels with out a change in ammonia. This suggests an adaptation in the compartmental nature of the glutamate-ammonia-glutamine metabolic system to provide more brain osmoles without excess ammonia. The brain: blood glucose ratio rose suggesting brain energy use rate reductions previously reported may be due to altered glucose transport or phosphorylation.

KW - brain ammonia

KW - brain glucose

KW - brain glutamine

KW - compartmentation

KW - hyperosmolality

KW - metabolic

UR - https://www.scopus.com/pages/publications/0018854374

U2 - 10.1016/0006-8993(80)91112-9

DO - 10.1016/0006-8993(80)91112-9

M3 - Article

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VL - 200

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JO - Brain Research

JF - Brain Research

IS - 1

ER -

Adaptation to hyperosmolality in the rat

Abstract

Keywords

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