Acute myeloid leukemia and diabetes insipidus with monosomy 7

Antoine Harb; Wei Tan; Gregory E. Wilding; Minoo Battiwalla; Sheila N.J. Sait; Eunice S. Wang; Meir Wetzler

doi:10.1016/j.cancergencyto.2009.01.006

Acute myeloid leukemia and diabetes insipidus with monosomy 7

Antoine Harb
, Wei Tan
, Gregory E. Wilding
, Minoo Battiwalla
, Sheila N.J. Sait
, Eunice S. Wang
, Meir Wetzler

Department of Biostatistics

Roswell Park Cancer Institute
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	190
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.01.006
State	Published - Apr 15 2009

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10.1016/j.cancergencyto.2009.01.006

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title = "Acute myeloid leukemia and diabetes insipidus with monosomy 7",

abstract = "The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.",

author = "Antoine Harb and Wei Tan and Wilding, \{Gregory E.\} and Minoo Battiwalla and Sait, \{Sheila N.J.\} and Wang, \{Eunice S.\} and Meir Wetzler",

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T1 - Acute myeloid leukemia and diabetes insipidus with monosomy 7

AU - Harb, Antoine

AU - Tan, Wei

AU - Wilding, Gregory E.

AU - Battiwalla, Minoo

AU - Sait, Sheila N.J.

AU - Wang, Eunice S.

AU - Wetzler, Meir

PY - 2009/4/15

Y1 - 2009/4/15

N2 - The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.

AB - The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.

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AN - SCOPUS:64549140070

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SP - 97

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JO - Cancer Genetics and Cytogenetics

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ER -

Acute myeloid leukemia and diabetes insipidus with monosomy 7

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