Skip to main navigation Skip to search Skip to main content

Acute Effects of Ghlorothiazide on Plasma Electrolytes and Acid-Base Pattern of Nephrectomized Rats and Dogs

  • University of Michigan, Ann Arbor

Research output: Contribution to journalArticlepeer-review

Abstract

Chlorothiazide (a natriuretic antihypertensive drug), sulfamethoxypyrida-zine (another sulfonamide derivative lacking antihypertensive effect), and diazoxide (a sodium-retaining antihypertensive thiazide) were given to nephrectomized animals. The effects of these drugs on plasma electrolytes and acid-base pattern did not differ from that of 5% glucose solution alone. No acute extrarenal action of chlorothiazide on plasma electrolytes or acid-base balance was evident.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume110
Issue number2
DOIs
StatePublished - Jun 1962

Fingerprint

Dive into the research topics of 'Acute Effects of Ghlorothiazide on Plasma Electrolytes and Acid-Base Pattern of Nephrectomized Rats and Dogs'. Together they form a unique fingerprint.

Cite this