Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

Amy M. Gancarz; Zi Jun Wang; Gabrielle L. Schroeder; Diane Damez-Werno; Kevin M. Braunscheidel; Lauren E. Mueller; Monica S. Humby; Aaron Caccamise; Jennifer A. Martin; Karen C. Dietz; Rachael L. Neve; David M. Dietz

doi:10.1038/nn.4036

Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

Amy M. Gancarz
, Zi Jun Wang
, Gabrielle L. Schroeder
, Diane Damez-Werno
, Kevin M. Braunscheidel
, Lauren E. Mueller
, Monica S. Humby
, Aaron Caccamise
, Jennifer A. Martin
, Karen C. Dietz
, Rachael L. Neve
, David M. Dietz

Pharmacology and Toxicology

SUNY Buffalo
Icahn School of Medicine at Mount Sinai
Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.

Original language	English
Pages (from-to)	959-961
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4036
State	Published - Jun 25 2015

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10.1038/nn.4036

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@article{8ab4ca6c09c14326bc002a7f325438cc,

title = "Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity",

abstract = "Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.",

author = "Gancarz, \{Amy M.\} and Wang, \{Zi Jun\} and Schroeder, \{Gabrielle L.\} and Diane Damez-Werno and Braunscheidel, \{Kevin M.\} and Mueller, \{Lauren E.\} and Humby, \{Monica S.\} and Aaron Caccamise and Martin, \{Jennifer A.\} and Dietz, \{Karen C.\} and Neve, \{Rachael L.\} and Dietz, \{David M.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc.",

year = "2015",

month = jun,

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doi = "10.1038/nn.4036",

language = "English",

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T1 - Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

AU - Gancarz, Amy M.

AU - Wang, Zi Jun

AU - Schroeder, Gabrielle L.

AU - Damez-Werno, Diane

AU - Braunscheidel, Kevin M.

AU - Mueller, Lauren E.

AU - Humby, Monica S.

AU - Caccamise, Aaron

AU - Martin, Jennifer A.

AU - Dietz, Karen C.

AU - Neve, Rachael L.

AU - Dietz, David M.

PY - 2015/6/25

Y1 - 2015/6/25

N2 - Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.

AB - Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.

UR - https://www.scopus.com/pages/publications/84933280412

U2 - 10.1038/nn.4036

DO - 10.1038/nn.4036

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JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

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Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity

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