Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Avinash Muppidi; Zhiyong Wang; Xiaolong Li; Jiandong Chen; Qing Lin

doi:10.1039/c1cc13320a

Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Avinash Muppidi
, Zhiyong Wang
, Xiaolong Li
, Jiandong Chen
, Qing Lin

Chemistry

SUNY Buffalo
Moffitt Cancer Center

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity.

Original language	English
Pages (from-to)	9396-9398
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	33
DOIs	https://doi.org/10.1039/c1cc13320a
State	Published - Sep 7 2011

Access to Document

10.1039/c1cc13320a

Cite this

@article{efe464b9a9a642cfb9524b1bc5fa8b8e,

title = "Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx",

abstract = "We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity.",

author = "Avinash Muppidi and Zhiyong Wang and Xiaolong Li and Jiandong Chen and Qing Lin",

year = "2011",

month = sep,

day = "7",

doi = "10.1039/c1cc13320a",

language = "English",

volume = "47",

pages = "9396--9398",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "33",

}

TY - JOUR

T1 - Achieving cell penetration with distance-matching cysteine cross-linkers

T2 - A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

AU - Muppidi, Avinash

AU - Wang, Zhiyong

AU - Li, Xiaolong

AU - Chen, Jiandong

AU - Lin, Qing

PY - 2011/9/7

Y1 - 2011/9/7

N2 - We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity.

AB - We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity.

UR - https://www.scopus.com/pages/publications/80051592173

U2 - 10.1039/c1cc13320a

DO - 10.1039/c1cc13320a

M3 - Article

C2 - 21773579

AN - SCOPUS:80051592173

SN - 1359-7345

VL - 47

SP - 9396

EP - 9398

JO - Chemical Communications

JF - Chemical Communications

IS - 33

ER -

Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Abstract

Access to Document

Other files and links

Fingerprint

Cite this