A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

Michalis Mastri; Amanda Tracz; Christina R. Lee; Melissa Dolan; Kristopher Attwood; James G. Christensen; Song Liu; John M.L. Ebos

doi:10.1016/j.celrep.2018.12.017

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

Michalis Mastri
, Amanda Tracz
, Christina R. Lee
, Melissa Dolan
, Kristopher Attwood
, James G. Christensen
, Song Liu
, John M.L. Ebos

Department of Biostatistics

Roswell Park Cancer Institute
University of Toronto
Pfizer

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Mastri et al. show that resistance to antiangiogenic therapy can induce senescence-mimicking secretory phenotypes that contribute to tumor promotion when treatment is stopped. Therapeutic targeting of senescence secretory regulators such as IL-6 and mTOR could improve outcomes after treatment failure.

Original language	English
Pages (from-to)	3706-3720.e8
Journal	Cell Reports
Volume	25
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2018.12.017
State	Published - Dec 26 2018

Keywords

antiangiogenic therapy
IL-6
metastasis
mTOR
rebound
resistance
SASP
secretome
senescence
VEGF RTKI

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10.1016/j.celrep.2018.12.017

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title = "A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal",

abstract = "Mastri et al. show that resistance to antiangiogenic therapy can induce senescence-mimicking secretory phenotypes that contribute to tumor promotion when treatment is stopped. Therapeutic targeting of senescence secretory regulators such as IL-6 and mTOR could improve outcomes after treatment failure.",

keywords = "antiangiogenic therapy, IL-6, metastasis, mTOR, rebound, resistance, SASP, secretome, senescence, VEGF RTKI",

author = "Michalis Mastri and Amanda Tracz and Lee, \{Christina R.\} and Melissa Dolan and Kristopher Attwood and Christensen, \{James G.\} and Song Liu and Ebos, \{John M.L.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s)",

year = "2018",

month = dec,

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doi = "10.1016/j.celrep.2018.12.017",

language = "English",

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T1 - A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

AU - Mastri, Michalis

AU - Tracz, Amanda

AU - Lee, Christina R.

AU - Dolan, Melissa

AU - Attwood, Kristopher

AU - Christensen, James G.

AU - Liu, Song

AU - Ebos, John M.L.

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Mastri et al. show that resistance to antiangiogenic therapy can induce senescence-mimicking secretory phenotypes that contribute to tumor promotion when treatment is stopped. Therapeutic targeting of senescence secretory regulators such as IL-6 and mTOR could improve outcomes after treatment failure.

AB - Mastri et al. show that resistance to antiangiogenic therapy can induce senescence-mimicking secretory phenotypes that contribute to tumor promotion when treatment is stopped. Therapeutic targeting of senescence secretory regulators such as IL-6 and mTOR could improve outcomes after treatment failure.

KW - antiangiogenic therapy

KW - IL-6

KW - metastasis

KW - mTOR

KW - rebound

KW - resistance

KW - SASP

KW - secretome

KW - senescence

KW - VEGF RTKI

UR - https://www.scopus.com/pages/publications/85058622793

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DO - 10.1016/j.celrep.2018.12.017

M3 - Article

C2 - 30590043

AN - SCOPUS:85058622793

SN - 2639-1856

VL - 25

SP - 3706-3720.e8

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

Abstract

Keywords

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