A six-stage workflow for robust application of systems pharmacology

K. Gadkar; D. C. Kirouac; D. E. Mager; P. H. Van Der Graaf; S. Ramanujan

doi:10.1002/psp4.12071

A six-stage workflow for robust application of systems pharmacology

K. Gadkar
, D. C. Kirouac
, D. E. Mager
, P. H. Van Der Graaf
, S. Ramanujan

Pharmaceutical Sciences

Genentech, Inc
Leiden University
Certara

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

Original language	English
Pages (from-to)	235-249
Number of pages	15
Journal	CPT: Pharmacometrics and Systems Pharmacology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1002/psp4.12071
State	Published - May 1 2016

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10.1002/psp4.12071

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AU - Ramanujan, S.

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AB - Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

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A six-stage workflow for robust application of systems pharmacology

Abstract

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