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A Schwann cell–neuron coculture system to study neuron–glia interaction during axon degeneration

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Autonomous mechanisms of axon degeneration are frequently studied in vitro by mechanical axon injury of isolated sensory neurons. This has led to major advances in understanding the molecular pathways governing axon degeneration. However, this approach does not pay attention to potential glial mechanisms for the regulation of axon death. Here, I describe a straightforward protocol to seed purified rat Schwann cells on neuronal cultures in order to study the interaction between axons and these glia during axon degeneration.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages97-110
Number of pages14
DOIs
StatePublished - 2020

Publication series

NameMethods in Molecular Biology
Volume2143
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Axon
  • Axon degeneration
  • Coculture
  • In vitro injury
  • Neuro–glia interaction
  • Schwann cell
  • Spot culture

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