A role for autoinhibition in preventing dimerization of the transcription factor ETS1

Daniel Samorodnitsky; Courtney Szyjka; Gerald B. Koudelka

doi:10.1074/jbc.M115.671339

A role for autoinhibition in preventing dimerization of the transcription factor ETS1

Daniel Samorodnitsky
, Courtney Szyjka
, Gerald B. Koudelka

Biological Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module. Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored. Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.

Original language	English
Pages (from-to)	22101-22110
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	290
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M115.671339
State	Published - Sep 4 2015

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title = "A role for autoinhibition in preventing dimerization of the transcription factor ETS1",

abstract = "Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module. Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored. Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.",

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AU - Koudelka, Gerald B.

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N2 - Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module. Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored. Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.

AB - Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module. Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored. Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.

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A role for autoinhibition in preventing dimerization of the transcription factor ETS1

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