A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states

Pavel B. Tsitovich; Joseph A. Spernyak; Janet R. Morrow

doi:10.1002/anie.201306394

A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states

Pavel B. Tsitovich
, Joseph A. Spernyak
, Janet R. Morrow

Chemistry

SUNY Buffalo
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Trigger ready: A redox-activated MRI contrast agent can cycle between paramagnetic Co^II (MRI-active) and diamagnetic Co^III (MRI-silent). The paramagnetic Co^II form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O₂ partial pressure and reductant concentration (thiols) on a time scale relevant to imaging. MT=magnetization transfer.

Original language	English
Pages (from-to)	13997-14000
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	52
DOIs	https://doi.org/10.1002/anie.201306394
State	Published - Dec 23 2013

Keywords

CEST imaging
cobalt
imaging agents
magnetic resonance imaging

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abstract = "Trigger ready: A redox-activated MRI contrast agent can cycle between paramagnetic CoII (MRI-active) and diamagnetic CoIII (MRI-silent). The paramagnetic CoII form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O2 partial pressure and reductant concentration (thiols) on a time scale relevant to imaging. MT=magnetization transfer.",

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KW - CEST imaging

KW - cobalt

KW - imaging agents

KW - magnetic resonance imaging

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A redox-activated MRI contrast agent that switches between paramagnetic and diamagnetic states

Abstract

Keywords

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