A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Haopeng Xiao; Mark P. Jedrychowski; Devin K. Schweppe; Edward L. Huttlin; Qing Yu; David E. Heppner; Jiaming Li; Jiani Long; Evanna L. Mills; John Szpyt; Zhixiang He; Guangyan Du; Ryan Garrity; Anita Reddy; Laura Pontano Vaites; Joao A. Paulo; Tinghu Zhang; Nathanael S. Gray; Steven P. Gygi; Edward T. Chouchani

doi:10.1016/j.cell.2020.02.012

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Haopeng Xiao
, Mark P. Jedrychowski
, Devin K. Schweppe
, Edward L. Huttlin
, Qing Yu
, David E. Heppner
, Jiaming Li
, Jiani Long
, Evanna L. Mills
, John Szpyt
, Zhixiang He
, Guangyan Du
, Ryan Garrity
, Anita Reddy
, Laura Pontano Vaites
, Joao A. Paulo
, Tinghu Zhang
, Nathanael S. Gray
, Steven P. Gygi
, Edward T. Chouchani

Chemistry

Dana-Farber Cancer Institute
Harvard University
Georgia Institute of Technology

Research output: Contribution to journal › Article › peer-review

354 Scopus citations

Abstract

A technology to study the tissue-specific effects of redox signaling enables a deeper understanding of the role of ROS in physiology and aging.

Original language	English
Pages (from-to)	968-983.e24
Journal	Cell
Volume	180
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.02.012
State	Published - Mar 5 2020

Keywords

ROS
aging
cysteine
proteomics
reactive oxygen species

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10.1016/j.cell.2020.02.012

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Xiao, H., Jedrychowski, M. P., Schweppe, D. K., Huttlin, E. L., Yu, Q., Heppner, D. E., Li, J., Long, J., Mills, E. L., Szpyt, J., He, Z., Du, G., Garrity, R., Reddy, A., Vaites, L. P., Paulo, J. A., Zhang, T., Gray, N. S., Gygi, S. P., & Chouchani, E. T. (2020). A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell, 180(5), 968-983.e24. https://doi.org/10.1016/j.cell.2020.02.012

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title = "A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging",

abstract = "A technology to study the tissue-specific effects of redox signaling enables a deeper understanding of the role of ROS in physiology and aging.",

keywords = "ROS, aging, cysteine, proteomics, reactive oxygen species",

author = "Haopeng Xiao and Jedrychowski, \{Mark P.\} and Schweppe, \{Devin K.\} and Huttlin, \{Edward L.\} and Qing Yu and Heppner, \{David E.\} and Jiaming Li and Jiani Long and Mills, \{Evanna L.\} and John Szpyt and Zhixiang He and Guangyan Du and Ryan Garrity and Anita Reddy and Vaites, \{Laura Pontano\} and Paulo, \{Joao A.\} and Tinghu Zhang and Gray, \{Nathanael S.\} and Gygi, \{Steven P.\} and Chouchani, \{Edward T.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = mar,

day = "5",

doi = "10.1016/j.cell.2020.02.012",

language = "English",

volume = "180",

pages = "968--983.e24",

journal = "Cell",

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}

Xiao, H, Jedrychowski, MP, Schweppe, DK, Huttlin, EL, Yu, Q, Heppner, DE, Li, J, Long, J, Mills, EL, Szpyt, J, He, Z, Du, G, Garrity, R, Reddy, A, Vaites, LP, Paulo, JA, Zhang, T, Gray, NS, Gygi, SP & Chouchani, ET 2020, 'A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging', Cell, vol. 180, no. 5, pp. 968-983.e24. https://doi.org/10.1016/j.cell.2020.02.012

TY - JOUR

T1 - A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

AU - Xiao, Haopeng

AU - Jedrychowski, Mark P.

AU - Schweppe, Devin K.

AU - Huttlin, Edward L.

AU - Yu, Qing

AU - Heppner, David E.

AU - Li, Jiaming

AU - Long, Jiani

AU - Mills, Evanna L.

AU - Szpyt, John

AU - He, Zhixiang

AU - Du, Guangyan

AU - Garrity, Ryan

AU - Reddy, Anita

AU - Vaites, Laura Pontano

AU - Paulo, Joao A.

AU - Zhang, Tinghu

AU - Gray, Nathanael S.

AU - Gygi, Steven P.

AU - Chouchani, Edward T.

PY - 2020/3/5

Y1 - 2020/3/5

N2 - A technology to study the tissue-specific effects of redox signaling enables a deeper understanding of the role of ROS in physiology and aging.

AB - A technology to study the tissue-specific effects of redox signaling enables a deeper understanding of the role of ROS in physiology and aging.

KW - ROS

KW - aging

KW - cysteine

KW - proteomics

KW - reactive oxygen species

UR - https://www.scopus.com/pages/publications/85080141830

U2 - 10.1016/j.cell.2020.02.012

DO - 10.1016/j.cell.2020.02.012

M3 - Article

C2 - 32109415

AN - SCOPUS:85080141830

SN - 0092-8674

VL - 180

SP - 968-983.e24

JO - Cell

JF - Cell

IS - 5

ER -

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Abstract

Keywords

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