Abstract
A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.
| Original language | English |
|---|---|
| Pages (from-to) | 3175-3182 |
| Number of pages | 8 |
| Journal | FEBS Letters |
| Volume | 579 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jun 6 2005 |
Keywords
- Alpha/beta hydrolase
- Bacillus
- Fold recognition
- ORFans
- Structure prediction
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