A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

Qing Lan; Unhee Lim; Chin San Liu; Stephanie J. Weinstein; Stephen Chanock; Matthew R. Bonner; Jarmo Virtamo; Demetrius Albanes; Nathaniel Rothman

doi:10.1182/blood-2008-05-157974

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

Qing Lan
, Unhee Lim
, Chin San Liu
, Stephanie J. Weinstein
, Stephen Chanock
, Matthew R. Bonner
, Jarmo Virtamo
, Demetrius Albanes
, Nathaniel Rothman

Department of Epidemiology and Environmental Health

National Institutes of Health
University of Hawai'i at Mānoa
Changhua Christian Hospital
National Institute for Health and Welfare

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

MitochondrialDNA(mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma andEpstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor.We hypothesized that having a higher mtDNA copy number in peripheral white blood cellDNAfrom healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a doseresponse relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/ SLL.

Original language	English
Pages (from-to)	4247-4249
Number of pages	3
Journal	Blood
Volume	112
Issue number	10
DOIs	https://doi.org/10.1182/blood-2008-05-157974
State	Published - Nov 15 2008

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title = "A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma",

abstract = "MitochondrialDNA(mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma andEpstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor.We hypothesized that having a higher mtDNA copy number in peripheral white blood cellDNAfrom healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a doseresponse relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95\% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/ SLL.",

author = "Qing Lan and Unhee Lim and Liu, \{Chin San\} and Weinstein, \{Stephanie J.\} and Stephen Chanock and Bonner, \{Matthew R.\} and Jarmo Virtamo and Demetrius Albanes and Nathaniel Rothman",

year = "2008",

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doi = "10.1182/blood-2008-05-157974",

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T1 - A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

AU - Lan, Qing

AU - Lim, Unhee

AU - Liu, Chin San

AU - Weinstein, Stephanie J.

AU - Chanock, Stephen

AU - Bonner, Matthew R.

AU - Virtamo, Jarmo

AU - Albanes, Demetrius

AU - Rothman, Nathaniel

PY - 2008/11/15

Y1 - 2008/11/15

N2 - MitochondrialDNA(mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma andEpstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor.We hypothesized that having a higher mtDNA copy number in peripheral white blood cellDNAfrom healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a doseresponse relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/ SLL.

AB - MitochondrialDNA(mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma andEpstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor.We hypothesized that having a higher mtDNA copy number in peripheral white blood cellDNAfrom healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a doseresponse relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/ SLL.

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DO - 10.1182/blood-2008-05-157974

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C2 - 18711000

AN - SCOPUS:58149145905

SN - 0006-4971

VL - 112

SP - 4247

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JO - Blood

JF - Blood

IS - 10

ER -

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

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