A photoactivated prodrug

Yaoming Wei; Yinfa Yan; Dehua Pei; Bing Gong

doi:10.1016/S0960-894X(98)00437-5

A photoactivated prodrug

Yaoming Wei
, Yinfa Yan
, Dehua Pei
, Bing Gong

Chemistry

Ohio State University
University of Toledo

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A photolabile derivative (1) of the anticancer drug, 5- fluorodeoxyuridine (2), was designed and synthesized as a model prodrag. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.

Original language	English
Pages (from-to)	2419-2422
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(98)00437-5
State	Published - Sep 22 1998

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10.1016/S0960-894X(98)00437-5

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title = "A photoactivated prodrug",

abstract = "A photolabile derivative (1) of the anticancer drug, 5- fluorodeoxyuridine (2), was designed and synthesized as a model prodrag. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.",

author = "Yaoming Wei and Yinfa Yan and Dehua Pei and Bing Gong",

year = "1998",

month = sep,

day = "22",

doi = "10.1016/S0960-894X(98)00437-5",

language = "English",

volume = "8",

pages = "2419--2422",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Ltd",

number = "18",

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TY - JOUR

T1 - A photoactivated prodrug

AU - Wei, Yaoming

AU - Yan, Yinfa

AU - Pei, Dehua

AU - Gong, Bing

PY - 1998/9/22

Y1 - 1998/9/22

N2 - A photolabile derivative (1) of the anticancer drug, 5- fluorodeoxyuridine (2), was designed and synthesized as a model prodrag. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.

AB - A photolabile derivative (1) of the anticancer drug, 5- fluorodeoxyuridine (2), was designed and synthesized as a model prodrag. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.

UR - https://www.scopus.com/pages/publications/17044442290

U2 - 10.1016/S0960-894X(98)00437-5

DO - 10.1016/S0960-894X(98)00437-5

M3 - Article

C2 - 9873553

AN - SCOPUS:17044442290

SN - 0960-894X

VL - 8

SP - 2419

EP - 2422

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

A photoactivated prodrug

Abstract

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