A permutation test approach to phase II historical control trials

Alan D. Hutson; Maurie Markman; Mark F. Brady

doi:10.1080/02664760802474280

A permutation test approach to phase II historical control trials

Alan D. Hutson
, Maurie Markman
, Mark F. Brady

Department of Biostatistics

University of Texas MD Anderson Cancer Center
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology.

Original language	English
Pages (from-to)	589-599
Number of pages	11
Journal	Journal of Applied Statistics
Volume	36
Issue number	6
DOIs	https://doi.org/10.1080/02664760802474280
State	Published - Jun 2009

Keywords

Clinical trial
Non-randomized

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10.1080/02664760802474280

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title = "A permutation test approach to phase II historical control trials",

abstract = "In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology.",

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AB - In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology.

KW - Clinical trial

KW - Non-randomized

UR - https://www.scopus.com/pages/publications/70449371823

U2 - 10.1080/02664760802474280

DO - 10.1080/02664760802474280

M3 - Article

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VL - 36

SP - 589

EP - 599

JO - Journal of Applied Statistics

JF - Journal of Applied Statistics

IS - 6

ER -

A permutation test approach to phase II historical control trials

Abstract

Keywords

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