A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

David G. Hangauer

doi:10.1016/S0040-4039(01)92927-2

A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

David G. Hangauer

Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The trianion of 3-(β-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(β-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors.

Original language	English
Pages (from-to)	2439-2442
Number of pages	4
Journal	Tetrahedron Letters
Volume	22
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(01)92927-2
State	Published - 1981

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title = "A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors",

abstract = "The trianion of 3-(β-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(β-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors.",

author = "Hangauer, \{David G.\}",

year = "1981",

doi = "10.1016/S0040-4039(01)92927-2",

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journal = "Tetrahedron Letters",

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T1 - A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

AU - Hangauer, David G.

PY - 1981

Y1 - 1981

N2 - The trianion of 3-(β-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(β-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors.

AB - The trianion of 3-(β-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(β-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors.

UR - https://www.scopus.com/pages/publications/0007015361

U2 - 10.1016/S0040-4039(01)92927-2

DO - 10.1016/S0040-4039(01)92927-2

M3 - Article

AN - SCOPUS:0007015361

SN - 0040-4039

VL - 22

SP - 2439

EP - 2442

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors

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