A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

Guolin Li; Ricky Mehta; Thamarapu Srikrishnan; Daniel J. Nurco; Walter A. Tabaczynski; James L. Alderfer; Kevin M. Smith; Thomas J. Dougherty; Ravindra K. Pandey

doi:10.1039/b202280j

A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

Guolin Li
, Ricky Mehta
, Thamarapu Srikrishnan
, Daniel J. Nurco
, Walter A. Tabaczynski
, James L. Alderfer
, Kevin M. Smith
, Thomas J. Dougherty
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

PDT Center and Nuclear Medicine
Roswell Park Cancer Institute
University of California at Davis

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH₃)₃SiCN-Cu(OTf)₂ produced unexpected 10³-trimethylsiloxyl and 10³-hydroxyl fused propenochlorins which, in H₂SO₄, underwent subsequent migration of the 8-ethyl group to the 10³-position of the exocyclic benzene ring to form a novel benzochlorin.

Original language	English
Pages (from-to)	1172-1173
Number of pages	2
Journal	Chemical Communications
Volume	11
DOIs	https://doi.org/10.1039/b202280j
State	Published - May 23 2002

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10.1039/b202280j

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title = "A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes",

abstract = "Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN-Cu(OTf)2 produced unexpected 103-trimethylsiloxyl and 103-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 103-position of the exocyclic benzene ring to form a novel benzochlorin.",

author = "Guolin Li and Ricky Mehta and Thamarapu Srikrishnan and Nurco, \{Daniel J.\} and Tabaczynski, \{Walter A.\} and Alderfer, \{James L.\} and Smith, \{Kevin M.\} and Dougherty, \{Thomas J.\} and Pandey, \{Ravindra K.\}",

year = "2002",

month = may,

day = "23",

doi = "10.1039/b202280j",

language = "English",

volume = "11",

pages = "1172--1173",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

AU - Li, Guolin

AU - Mehta, Ricky

AU - Srikrishnan, Thamarapu

AU - Nurco, Daniel J.

AU - Tabaczynski, Walter A.

AU - Alderfer, James L.

AU - Smith, Kevin M.

AU - Dougherty, Thomas J.

AU - Pandey, Ravindra K.

PY - 2002/5/23

Y1 - 2002/5/23

N2 - Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN-Cu(OTf)2 produced unexpected 103-trimethylsiloxyl and 103-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 103-position of the exocyclic benzene ring to form a novel benzochlorin.

AB - Reaction of meso-(2-formylvinyl)octaethylporphyrin with (CH3)3SiCN-Cu(OTf)2 produced unexpected 103-trimethylsiloxyl and 103-hydroxyl fused propenochlorins which, in H2SO4, underwent subsequent migration of the 8-ethyl group to the 103-position of the exocyclic benzene ring to form a novel benzochlorin.

UR - https://www.scopus.com/pages/publications/0037161766

U2 - 10.1039/b202280j

DO - 10.1039/b202280j

M3 - Article

C2 - 12109067

AN - SCOPUS:0037161766

SN - 1359-7345

VL - 11

SP - 1172

EP - 1173

JO - Chemical Communications

JF - Chemical Communications

ER -

A novel synthetic route to fused propenochlorin and benzochlorin photodynamic therapy probes

Abstract

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