A novel method for the analysis of the androgen receptor

Kris E. Gaston; O. Harris Ford; Swaroop Singh; Christopher W. Gregory; Donald E. Weyel; Gary J. Smith; James L. Mohler

doi:10.1007/s11934-002-0013-8

A novel method for the analysis of the androgen receptor

Kris E. Gaston
, O. Harris Ford
, Swaroop Singh
, Christopher W. Gregory
, Donald E. Weyel
, Gary J. Smith
, James L. Mohler

Department of Urology

University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computerassisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.

Original language	English
Pages (from-to)	67-74
Number of pages	8
Journal	Current Urology Reports
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s11934-002-0013-8
State	Published - Feb 2002

Keywords

Androgen
Androgen Receptor
Androgen Receptor Expression
Benign Prostatic Hyperplasia
Prostate Cancer

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10.1007/s11934-002-0013-8

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title = "A novel method for the analysis of the androgen receptor",

abstract = "The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computerassisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.",

keywords = "Androgen, Androgen Receptor, Androgen Receptor Expression, Benign Prostatic Hyperplasia, Prostate Cancer",

author = "Gaston, \{Kris E.\} and \{Harris Ford\}, O. and Swaroop Singh and Gregory, \{Christopher W.\} and Weyel, \{Donald E.\} and Smith, \{Gary J.\} and Mohler, \{James L.\}",

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doi = "10.1007/s11934-002-0013-8",

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AU - Gaston, Kris E.

AU - Harris Ford, O.

AU - Singh, Swaroop

AU - Gregory, Christopher W.

AU - Weyel, Donald E.

AU - Smith, Gary J.

AU - Mohler, James L.

PY - 2002/2

Y1 - 2002/2

N2 - The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computerassisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.

AB - The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computerassisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.

KW - Androgen

KW - Androgen Receptor

KW - Androgen Receptor Expression

KW - Benign Prostatic Hyperplasia

KW - Prostate Cancer

UR - https://www.scopus.com/pages/publications/0036481432

U2 - 10.1007/s11934-002-0013-8

DO - 10.1007/s11934-002-0013-8

M3 - Article

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AN - SCOPUS:0036481432

SN - 1527-2737

VL - 3

SP - 67

EP - 74

JO - Current Urology Reports

JF - Current Urology Reports

IS - 1

ER -

A novel method for the analysis of the androgen receptor

Abstract

Keywords

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