A novel bacteriochlorin-gold nanoparticle construct for photoacoustic imaging

Avinash Srivatsan; Mansik Jeon; Yanfang Wang; Yihui Chen; Chulhong Kim; Ravindra K. Pandey

doi:10.1142/S1088424616500358

A novel bacteriochlorin-gold nanoparticle construct for photoacoustic imaging

Avinash Srivatsan
, Mansik Jeon
, Yanfang Wang
, Yihui Chen
, Chulhong Kim
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute
SUNY Buffalo
Pohang University of Science and Technology
Kyungpook National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Herein we report the synthesis of new gold nanoparticle-bacteriochlorin conjugate (Au-NP-PS) as a highly efficient photoacoustic (PA) imaging agent. The conjugate was obtained by reacting a water soluble thio-bacteriochlorin (derived from bacteriochlorophyll-a) with Au-NP. The resulting NPs were characterized by UV-vis, TEM (transmission electron microscopy)/HRTEM (high resolution TEM) and diffraction pattern. The results obtained from in vitro studies suggest that due to conjugation between the PS and Au-NPs, the photoacoustic (PA) signals from the Au-NP-PS were greatly enhanced by a factor of 2.4 compared to that from PS alone.

Original language	English
Pages (from-to)	490-496
Number of pages	7
Journal	Journal of Porphyrins and Phthalocyanines
Volume	20
Issue number	1-4
DOIs	https://doi.org/10.1142/S1088424616500358
State	Published - Apr 1 2016

Keywords

fluorescence imaging
gold nanoparticles
near infrared
photoacoustic imaging
photodynamic therapy
photothermal therapy
transmission electron microscopy

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10.1142/S1088424616500358

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title = "A novel bacteriochlorin-gold nanoparticle construct for photoacoustic imaging",

abstract = "Herein we report the synthesis of new gold nanoparticle-bacteriochlorin conjugate (Au-NP-PS) as a highly efficient photoacoustic (PA) imaging agent. The conjugate was obtained by reacting a water soluble thio-bacteriochlorin (derived from bacteriochlorophyll-a) with Au-NP. The resulting NPs were characterized by UV-vis, TEM (transmission electron microscopy)/HRTEM (high resolution TEM) and diffraction pattern. The results obtained from in vitro studies suggest that due to conjugation between the PS and Au-NPs, the photoacoustic (PA) signals from the Au-NP-PS were greatly enhanced by a factor of 2.4 compared to that from PS alone.",

keywords = "fluorescence imaging, gold nanoparticles, near infrared, photoacoustic imaging, photodynamic therapy, photothermal therapy, transmission electron microscopy",

author = "Avinash Srivatsan and Mansik Jeon and Yanfang Wang and Yihui Chen and Chulhong Kim and Pandey, \{Ravindra K.\}",

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language = "English",

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TY - JOUR

T1 - A novel bacteriochlorin-gold nanoparticle construct for photoacoustic imaging

AU - Srivatsan, Avinash

AU - Jeon, Mansik

AU - Wang, Yanfang

AU - Chen, Yihui

AU - Kim, Chulhong

AU - Pandey, Ravindra K.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Herein we report the synthesis of new gold nanoparticle-bacteriochlorin conjugate (Au-NP-PS) as a highly efficient photoacoustic (PA) imaging agent. The conjugate was obtained by reacting a water soluble thio-bacteriochlorin (derived from bacteriochlorophyll-a) with Au-NP. The resulting NPs were characterized by UV-vis, TEM (transmission electron microscopy)/HRTEM (high resolution TEM) and diffraction pattern. The results obtained from in vitro studies suggest that due to conjugation between the PS and Au-NPs, the photoacoustic (PA) signals from the Au-NP-PS were greatly enhanced by a factor of 2.4 compared to that from PS alone.

AB - Herein we report the synthesis of new gold nanoparticle-bacteriochlorin conjugate (Au-NP-PS) as a highly efficient photoacoustic (PA) imaging agent. The conjugate was obtained by reacting a water soluble thio-bacteriochlorin (derived from bacteriochlorophyll-a) with Au-NP. The resulting NPs were characterized by UV-vis, TEM (transmission electron microscopy)/HRTEM (high resolution TEM) and diffraction pattern. The results obtained from in vitro studies suggest that due to conjugation between the PS and Au-NPs, the photoacoustic (PA) signals from the Au-NP-PS were greatly enhanced by a factor of 2.4 compared to that from PS alone.

KW - fluorescence imaging

KW - gold nanoparticles

KW - near infrared

KW - photoacoustic imaging

KW - photodynamic therapy

KW - photothermal therapy

KW - transmission electron microscopy

UR - https://www.scopus.com/pages/publications/84966908010

U2 - 10.1142/S1088424616500358

DO - 10.1142/S1088424616500358

M3 - Article

AN - SCOPUS:84966908010

SN - 1088-4246

VL - 20

SP - 490

EP - 496

JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

IS - 1-4

ER -

A novel bacteriochlorin-gold nanoparticle construct for photoacoustic imaging

Abstract

Keywords

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