A first comparative study of purpurinimide-based fluorinated vs. Nonfluorinated photosensitizers for photodynamic therapy

Amy L. Gryshuk; Andrew Graham; Suresh K. Pandey; William R. Potter; Joseph R. Missert; Allan Oseroff; Thomas J. Dougherty; Ravindra K. Pandey

doi:10.1562/0031-8655(2002)076<0555:AFCSOP>2.0.CO;2

A first comparative study of purpurinimide-based fluorinated vs. Nonfluorinated photosensitizers for photodynamic therapy

Amy L. Gryshuk
, Andrew Graham
, Suresh K. Pandey
, William R. Potter
, Joseph R. Missert
, Allan Oseroff
, Thomas J. Dougherty
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A first report on the synthesis and comparative in vitro-in vivo photosensitizing efficacy of various fluorinated and the corresponding nonfluorinated, purpurinimide-based photosensitizers is discussed. In preliminary in vivo screening, compared with the nonfluorinated analogs, purpurinimides bearing trifluoromethyl substituents showed enhanced photosensitizing efficacy. Among compounds (isomers) with similar lipophilicity, the position of the substituents was found to play a decisive role in biological efficacy.

Original language	English
Pages (from-to)	555-559
Number of pages	5
Journal	Photochemistry and Photobiology
Volume	76
Issue number	5
DOIs	https://doi.org/10.1562/0031-8655(2002)076<0555:AFCSOP>2.0.CO;2
State	Published - Nov 1 2002

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title = "A first comparative study of purpurinimide-based fluorinated vs. Nonfluorinated photosensitizers for photodynamic therapy",

abstract = "A first report on the synthesis and comparative in vitro-in vivo photosensitizing efficacy of various fluorinated and the corresponding nonfluorinated, purpurinimide-based photosensitizers is discussed. In preliminary in vivo screening, compared with the nonfluorinated analogs, purpurinimides bearing trifluoromethyl substituents showed enhanced photosensitizing efficacy. Among compounds (isomers) with similar lipophilicity, the position of the substituents was found to play a decisive role in biological efficacy.",

author = "Gryshuk, \{Amy L.\} and Andrew Graham and Pandey, \{Suresh K.\} and Potter, \{William R.\} and Missert, \{Joseph R.\} and Allan Oseroff and Dougherty, \{Thomas J.\} and Pandey, \{Ravindra K.\}",

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AU - Gryshuk, Amy L.

AU - Graham, Andrew

AU - Pandey, Suresh K.

AU - Potter, William R.

AU - Missert, Joseph R.

AU - Oseroff, Allan

AU - Dougherty, Thomas J.

AU - Pandey, Ravindra K.

PY - 2002/11/1

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N2 - A first report on the synthesis and comparative in vitro-in vivo photosensitizing efficacy of various fluorinated and the corresponding nonfluorinated, purpurinimide-based photosensitizers is discussed. In preliminary in vivo screening, compared with the nonfluorinated analogs, purpurinimides bearing trifluoromethyl substituents showed enhanced photosensitizing efficacy. Among compounds (isomers) with similar lipophilicity, the position of the substituents was found to play a decisive role in biological efficacy.

AB - A first report on the synthesis and comparative in vitro-in vivo photosensitizing efficacy of various fluorinated and the corresponding nonfluorinated, purpurinimide-based photosensitizers is discussed. In preliminary in vivo screening, compared with the nonfluorinated analogs, purpurinimides bearing trifluoromethyl substituents showed enhanced photosensitizing efficacy. Among compounds (isomers) with similar lipophilicity, the position of the substituents was found to play a decisive role in biological efficacy.

UR - https://www.scopus.com/pages/publications/0036877763

U2 - 10.1562/0031-8655(2002)076<0555:AFCSOP>2.0.CO;2

DO - 10.1562/0031-8655(2002)076<0555:AFCSOP>2.0.CO;2

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JO - Photochemistry and Photobiology

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IS - 5

ER -

A first comparative study of purpurinimide-based fluorinated vs. Nonfluorinated photosensitizers for photodynamic therapy

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