A double‐blind study of neurotropin in patients with acute ischemic stroke

J. De Reuck; D. Decoo; P. Vanderdonckt; A. Dallenga; W. Ceusters; J. P. Kalala; K. De Meulemeester; J. Abdullah; P. Santens; J. Huybrechts; R. Spiers; J. De Bleecker; I. Tack; E. Tack; C. Vogels; P. Boon

doi:10.1111/j.1600-0404.1994.tb02643.x

A double‐blind study of neurotropin in patients with acute ischemic stroke

J. De Reuck
, D. Decoo
, P. Vanderdonckt
, A. Dallenga
, W. Ceusters
, J. P. Kalala
, K. De Meulemeester
, J. Abdullah
, P. Santens
, J. Huybrechts
, R. Spiers
, J. De Bleecker
, I. Tack
, E. Tack
, C. Vogels
, P. Boon

Department of Biomedical Informatics

Ghent University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea‐pig. A randomized double‐blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo‐randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo‐treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo‐treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CTscans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.

Original language	English
Pages (from-to)	329-335
Number of pages	7
Journal	Acta Neurologica Scandinavica
Volume	89
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0404.1994.tb02643.x
State	Published - May 1994

Keywords

ischemic stroke
neurotropin treatment
vasogenic oedema

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10.1111/j.1600-0404.1994.tb02643.x

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De Reuck, J., Decoo, D., Vanderdonckt, P., Dallenga, A., Ceusters, W., Kalala, J. P., De Meulemeester, K., Abdullah, J., Santens, P., Huybrechts, J., Spiers, R., De Bleecker, J., Tack, I., Tack, E., Vogels, C., & Boon, P. (1994). A double‐blind study of neurotropin in patients with acute ischemic stroke. Acta Neurologica Scandinavica, 89(5), 329-335. https://doi.org/10.1111/j.1600-0404.1994.tb02643.x

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title = "A double‐blind study of neurotropin in patients with acute ischemic stroke",

abstract = "Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea‐pig. A randomized double‐blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo‐randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo‐treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo‐treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CTscans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.",

keywords = "ischemic stroke, neurotropin treatment, vasogenic oedema",

author = "\{De Reuck\}, J. and D. Decoo and P. Vanderdonckt and A. Dallenga and W. Ceusters and Kalala, \{J. P.\} and \{De Meulemeester\}, K. and J. Abdullah and P. Santens and J. Huybrechts and R. Spiers and \{De Bleecker\}, J. and I. Tack and E. Tack and C. Vogels and P. Boon",

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doi = "10.1111/j.1600-0404.1994.tb02643.x",

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De Reuck, J, Decoo, D, Vanderdonckt, P, Dallenga, A, Ceusters, W, Kalala, JP, De Meulemeester, K, Abdullah, J, Santens, P, Huybrechts, J, Spiers, R, De Bleecker, J, Tack, I, Tack, E, Vogels, C & Boon, P 1994, 'A double‐blind study of neurotropin in patients with acute ischemic stroke', Acta Neurologica Scandinavica, vol. 89, no. 5, pp. 329-335. https://doi.org/10.1111/j.1600-0404.1994.tb02643.x

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AU - Decoo, D.

AU - Vanderdonckt, P.

AU - Dallenga, A.

AU - Ceusters, W.

AU - Kalala, J. P.

AU - De Meulemeester, K.

AU - Abdullah, J.

AU - Santens, P.

AU - Huybrechts, J.

AU - Spiers, R.

AU - De Bleecker, J.

AU - Tack, I.

AU - Tack, E.

AU - Vogels, C.

AU - Boon, P.

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AB - Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea‐pig. A randomized double‐blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo‐randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo‐treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo‐treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CTscans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.

KW - ischemic stroke

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KW - vasogenic oedema

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ER -

A double‐blind study of neurotropin in patients with acute ischemic stroke

Abstract

Keywords

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