A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et2O catalyzed amino-claisen rearrangement.

Gaifa Lai; Wayne K. Anderson

doi:10.1016/S0040-4039(00)91811-2

A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et₂O catalyzed amino-claisen rearrangement.

Gaifa Lai
, Wayne K. Anderson

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A nine-step synthesis of the benzimidazole analogue, 2, of mycophenolic acid is reported involving both the BF₃-Et₂O catalysed aromatic amino- and the ortho ester Claisen rearrangements as key steps.

Original language	English
Pages (from-to)	6849-6852
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	43
DOIs	https://doi.org/10.1016/S0040-4039(00)91811-2
State	Published - Oct 22 1993

Keywords

aromatic amino-Claisen rearrangement.
benzimidazole
mycophenolic acid

Access to Document

10.1016/S0040-4039(00)91811-2

Cite this

@article{67acb7902119455da0ccc0ef459e11fb,

title = "A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et2O catalyzed amino-claisen rearrangement.",

abstract = "A nine-step synthesis of the benzimidazole analogue, 2, of mycophenolic acid is reported involving both the BF3-Et2O catalysed aromatic amino- and the ortho ester Claisen rearrangements as key steps.",

keywords = "aromatic amino-Claisen rearrangement., benzimidazole, mycophenolic acid",

author = "Gaifa Lai and Anderson, \{Wayne K.\}",

year = "1993",

month = oct,

day = "22",

doi = "10.1016/S0040-4039(00)91811-2",

language = "English",

volume = "34",

pages = "6849--6852",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "43",

}

TY - JOUR

T1 - A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et2O catalyzed amino-claisen rearrangement.

AU - Lai, Gaifa

AU - Anderson, Wayne K.

PY - 1993/10/22

Y1 - 1993/10/22

N2 - A nine-step synthesis of the benzimidazole analogue, 2, of mycophenolic acid is reported involving both the BF3-Et2O catalysed aromatic amino- and the ortho ester Claisen rearrangements as key steps.

AB - A nine-step synthesis of the benzimidazole analogue, 2, of mycophenolic acid is reported involving both the BF3-Et2O catalysed aromatic amino- and the ortho ester Claisen rearrangements as key steps.

KW - aromatic amino-Claisen rearrangement.

KW - benzimidazole

KW - mycophenolic acid

UR - https://www.scopus.com/pages/publications/0027383511

U2 - 10.1016/S0040-4039(00)91811-2

DO - 10.1016/S0040-4039(00)91811-2

M3 - Article

AN - SCOPUS:0027383511

SN - 0040-4039

VL - 34

SP - 6849

EP - 6852

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

A concise synthesis of a benzimidazole analogue of mycophenolic acid using a BF3-Et₂O catalyzed amino-claisen rearrangement.

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this