@inproceedings{5c3225d4a4ec4039b9bf5fb91c8ef9bb,
title = "A 128-ch Neurochemical Microchip with Highly-Scalable Low-Noise Resistive Feedback Amplifiers",
abstract = "Neurochemical recordings based on electrochemical reactions of electroactive neurotransmitters (e.g., dopamine, serotonin, and norepinephrine) are used for highly-sensitive monitoring of neurotransmitters in the brain. While single-channel carbon-fiber microelectrode recordings have been the gold standard method, a microelectrode array can be used to capture high spatiotemporal resolution imaging of electroactive neurotransmitters. To enable neurochemical imaging from a microelectrode array, a high-density current-sensing microchip must be developed to amplify and process redox signals. Here, a neurochemical microchip with a 128-ch current sensing front-end to support 128 parallel neurochemical measurements is presented. The designed amplifier array uses a highly scalable resistive feedback transimpedance amplifier design to provide a large neurochemical dynamic range (± 5 μA) with low noise performance (0.22 nARMs). This microchip will enable in vivo neurochemical imaging of dopamine with high spatiotemporal resolution.",
keywords = "Current-sensing, dopamine, electrochemistry, fast-scan cyclic voltammetry, microelectrode array, neural interface, neurochemical recordings, neurotransmitters",
author = "White, \{Kevin A.\} and Jinwoo Park and Kim, \{Brian N.\}",
note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023 ; Conference date: 06-08-2023 Through 09-08-2023",
year = "2023",
doi = "10.1109/MWSCAS57524.2023.10405948",
language = "English",
series = "Midwest Symposium on Circuits and Systems",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "763--767",
booktitle = "2023 IEEE 66th International Midwest Symposium on Circuits and Systems, MWSCAS 2023",
address = "United States",
}