2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate

A. M. Triggle; D. J. Triggle

doi:10.1002/jps.2600540531

2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate

A. M. Triggle
, D. J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The synthesis of the title compound (VII) is described. The key intermediate in this synthesis was prepared from 1‐chloro‐2,3‐epoxypropane and ethyl‐p‐aminobenzoate. Preliminary biological data, including toxicity, and antitumor and folic reductase inhibitory actions, are presented.

Original language	English
Pages (from-to)	795-797
Number of pages	3
Journal	Journal of Pharmaceutical Sciences
Volume	54
Issue number	5
DOIs	https://doi.org/10.1002/jps.2600540531
State	Published - May 1965

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title = "2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate",

abstract = "The synthesis of the title compound (VII) is described. The key intermediate in this synthesis was prepared from 1‐chloro‐2,3‐epoxypropane and ethyl‐p‐aminobenzoate. Preliminary biological data, including toxicity, and antitumor and folic reductase inhibitory actions, are presented.",

author = "Triggle, \{A. M.\} and Triggle, \{D. J.\}",

year = "1965",

month = may,

doi = "10.1002/jps.2600540531",

language = "English",

volume = "54",

pages = "795--797",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier B.V.",

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}

2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate. / Triggle, A. M.; Triggle, D. J.
In: Journal of Pharmaceutical Sciences, Vol. 54, No. 5, 05.1965, p. 795-797.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate

AU - Triggle, A. M.

AU - Triggle, D. J.

PY - 1965/5

Y1 - 1965/5

N2 - The synthesis of the title compound (VII) is described. The key intermediate in this synthesis was prepared from 1‐chloro‐2,3‐epoxypropane and ethyl‐p‐aminobenzoate. Preliminary biological data, including toxicity, and antitumor and folic reductase inhibitory actions, are presented.

AB - The synthesis of the title compound (VII) is described. The key intermediate in this synthesis was prepared from 1‐chloro‐2,3‐epoxypropane and ethyl‐p‐aminobenzoate. Preliminary biological data, including toxicity, and antitumor and folic reductase inhibitory actions, are presented.

UR - https://www.scopus.com/pages/publications/0013781948

U2 - 10.1002/jps.2600540531

DO - 10.1002/jps.2600540531

M3 - Article

C2 - 5845898

AN - SCOPUS:0013781948

SN - 0022-3549

VL - 54

SP - 795

EP - 797

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 5

ER -

2‐halogenoethylamines as potential folic acid antagonists I. Synthesis and biological activity of ethyl‐N‐[1‐(2‐amino‐4‐hydroxy‐6‐methyl‐5‐pyrimidyl)‐3‐(2‐chloro)‐ propyl]‐p‐aminobenzoate

Abstract

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