2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactones: Structure and activity relationship in cytotoxic activity

Yong Kim; Young Jae You; Nguyen Hai Nam; Byung Zun Ahn

doi:10.1007/BF02976621

2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactones: Structure and activity relationship in cytotoxic activity

Yong Kim
, Young Jae You
, Nguyen Hai Nam
, Byung Zun Ahn

Pharmaceutical Sciences

Chungnam National University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C′-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.

Original language	English
Pages (from-to)	240-249
Number of pages	10
Journal	Archives of Pharmacal Research
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/BF02976621
State	Published - Jun 30 2002

Keywords

Cytotoxic activity
Deoxypodophyllotoxin analogues
Yatein analogues

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10.1007/BF02976621

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title = "2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactones: Structure and activity relationship in cytotoxic activity",

abstract = "Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C′-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.",

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TY - JOUR

T1 - 2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactones

T2 - Structure and activity relationship in cytotoxic activity

AU - Kim, Yong

AU - You, Young Jae

AU - Nam, Nguyen Hai

AU - Ahn, Byung Zun

PY - 2002/6/30

Y1 - 2002/6/30

N2 - Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C′-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.

AB - Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C′-2 in ring C were more cytotoxic, while dibenzyl-γ-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity.

KW - Cytotoxic activity

KW - Deoxypodophyllotoxin analogues

KW - Yatein analogues

UR - https://www.scopus.com/pages/publications/0036594845

U2 - 10.1007/BF02976621

DO - 10.1007/BF02976621

M3 - Article

C2 - 12135092

AN - SCOPUS:0036594845

SN - 0253-6269

VL - 25

SP - 240

EP - 249

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid γ-lactones: Structure and activity relationship in cytotoxic activity

Abstract

Keywords

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