@inproceedings{c5173fe88db8429fa307366047e768a8,
title = "2-layer based microfluidic dilution generator for drug screening",
abstract = "We present a 2-layer based microfluidic concentration generator by a hybrid serial and volumetric dilution for dose-response experiments in drug screening. We have designed a microfluidic dilution generator simultaneously covering 14 doses with a combination of 4-order logarithmic and 4-point linear concentrations. The design has been verified by a commercial circuit analysis software (P-Spice) for the electrical circuit analysis and a computational fluid dynamics software (CFD-ACE+) for the microfluidic circuit analysis. As a real-life application of the proposed dilution generator, we have successfully performed a dose-response experiment using MCF-7 human breast cancer cells.",
keywords = "Dilution, Drug screening, Microfluidic network, Serial dilution",
author = "Kangsun Lee and Choong Kim and Youngeun Kim and Keunhui Jung and Byungwook Ahn and Kang, \{Ji Yoon\} and Oh, \{Kwang W.\}",
year = "2009",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1264--1266",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}