1,4-Dihydropyridine activators in the tiamdipine series

F. Galletti; E. Luchowski; D. J. Triggle

doi:10.1016/0014-2999(90)90635-J

1,4-Dihydropyridine activators in the tiamdipine series

F. Galletti
, E. Luchowski
, D. J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca²⁺ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and an tagonist properties, the latter being exhibited at lower concentrations.

Original language	English
Pages (from-to)	157-161
Number of pages	5
Journal	European Journal of Pharmacology
Volume	185
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90635-J
State	Published - Aug 28 1990

Keywords

1,4-Dihydropyridines
Ca
Ca channel activators
Smooth muscle
Tiamdipine
[H]PN 200-110

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10.1016/0014-2999(90)90635-J

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title = "1,4-Dihydropyridine activators in the tiamdipine series",

abstract = "The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and an tagonist properties, the latter being exhibited at lower concentrations.",

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T1 - 1,4-Dihydropyridine activators in the tiamdipine series

AU - Galletti, F.

AU - Luchowski, E.

AU - Triggle, D. J.

PY - 1990/8/28

Y1 - 1990/8/28

N2 - The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and an tagonist properties, the latter being exhibited at lower concentrations.

AB - The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and an tagonist properties, the latter being exhibited at lower concentrations.

KW - 1,4-Dihydropyridines

KW - Ca

KW - Ca channel activators

KW - Smooth muscle

KW - Tiamdipine

KW - [H]PN 200-110

UR - https://www.scopus.com/pages/publications/0025125204

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DO - 10.1016/0014-2999(90)90635-J

M3 - Article

C2 - 2147653

AN - SCOPUS:0025125204

SN - 0014-2999

VL - 185

SP - 157

EP - 161

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

1,4-Dihydropyridine activators in the tiamdipine series

Abstract

Keywords

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