α2-Adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-α

Amy E. Renauld; Tracey A. Ignatowski; Robert N. Spengler

doi:10.1016/j.brainres.2004.01.029

α₂-Adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-α

Amy E. Renauld
, Tracey A. Ignatowski
, Robert N. Spengler

Department of Pathology and Anatomical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Activation of the α₂-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by α₂-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-α (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in α₂-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.

Original language	English
Pages (from-to)	212-216
Number of pages	5
Journal	Brain Research
Volume	1004
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.01.029
State	Published - Apr 9 2004

Keywords

α-Adrenergic receptor
Catecholamine receptors
Cyclic adenosine monophosphate
Neuron
Neurotransmitters, modulators, transporters, and receptors
Tumor necrosis factor-α

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10.1016/j.brainres.2004.01.029

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title = "α2-Adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-α",

abstract = "Activation of the α2-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by α2-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-α (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in α2-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.",

keywords = "α-Adrenergic receptor, Catecholamine receptors, Cyclic adenosine monophosphate, Neuron, Neurotransmitters, modulators, transporters, and receptors, Tumor necrosis factor-α",

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year = "2004",

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doi = "10.1016/j.brainres.2004.01.029",

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T1 - α2-Adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-α

AU - Renauld, Amy E.

AU - Ignatowski, Tracey A.

AU - Spengler, Robert N.

PY - 2004/4/9

Y1 - 2004/4/9

N2 - Activation of the α2-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by α2-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-α (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in α2-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.

AB - Activation of the α2-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by α2-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-α (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in α2-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.

KW - α-Adrenergic receptor

KW - Catecholamine receptors

KW - Cyclic adenosine monophosphate

KW - Neuron

KW - Neurotransmitters, modulators, transporters, and receptors

KW - Tumor necrosis factor-α

UR - https://www.scopus.com/pages/publications/1642304164

U2 - 10.1016/j.brainres.2004.01.029

DO - 10.1016/j.brainres.2004.01.029

M3 - Article

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AN - SCOPUS:1642304164

SN - 0006-8993

VL - 1004

SP - 212

EP - 216

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

α₂-Adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-α

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